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Trimethoprim Sulfa

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Types

Trimethoprim Sulfadiazine; Trimethoprim Sulfamethoxazole

 

Brands

Bactrim; Septra; Sulfatrim; Cotrim (Trimethoprim Sulfadiazine)

Tribrissen (Trimethoprim Sulfamethoxazole)

 

Description

An broad-spectrum anti-bacterial substance, used against a variety of bacterial organisms.

It is a combination of two active ingredients. Both affect a vitamin called folic acid and its activity in bacteria causing destruction of its metabolic function in the bacteria.

 

Uses

  • Certain urinary tract infections
  • Skin infections
  • Any secondary infections - bronchitis, pneumonia, Streptococci and some strains of Staphylococcus
  • Not effective against Mycoplasma

 

Dosage

  • 15mg/lb orally, twice a day (24)
  • 30 mg/kg orally or by injection twice a day (20)

 

Side Effects

  • Diarrhoea
  • Rash and/or itching
  • Anaphylaxis (exaggerated allergic reaction on second dose if this state develops)
  • Joint inflammation

 

Warnings

  • Keep rat well hydrated
  • Birth defects have been reported after this medication was given to pregnant rats (21)

 

Combinations

[Amikacin] [Gentamicin]

 

References: [19] [20] [21] [24]

Wed, 12/05/2007 - 08:24 — admin

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